The Transgenic Mouse Model

To test whether the fusion-competent (FC) vaccine immunogen can elicit neutralizing antibodies, transgenic mice that express hu CD4 and hu CCR5 coreceptor were used.

What are two reason why?

one reason why? mimics human case: This animal model was immunologically tolerant to the human (hu) CD4 and CCR5 components of the vaccine.

another reason why? did not want antibodies to CD4 and CCR5 to confound results

On to the Transgenic Mouse Pilot Experiment

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