Chimeric mutant construction

 

1. For each chimeric mutant the domain of M2 was replaced with or NA.
For the delta mutant to be constructed, there were two stop codons at the 3' end of the M1  

2. Transfect 293 T cells with the chimeric plasmids.

3. Supernatant of the transfected plasmids was assayed and observed.

 

Schematic diagram of the chimeric M2 mutants and the M2 lacking the TM and cytoplasmic domains  

 

 Why use chimeric mutants?

 

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